摘要：Figure 5. Enhancement on mitophagy by TPP-rHuHF-LYC nanodots through the PINK1/Parkin-mediated signaling pathway. (A) The protein

2024年度大连工业大学食品学院在ACS Nano发表一篇文章：Facilitating Pro-survival Mitophagy for Alleviating Parkinson’s Disease via Sequence-Targeted Lycopene Nanodots。

ACS Nano (2023) ，Xiaoyu Xia为该文章第一作者，Xianbing Xu及Ming Du为通讯作者。

质疑内容：

近日，国际评阅人Carmichaelia astonii 指出此文章WB条带存在重复嫌疑：

Figure 2 H and Figure 4 G show the similar WB bands in different tests

Also, Figure 5 E,G, and J have the same problems!

Would the authors please provide the original gel bands and comment?

I've added the rectangle with the same colors to show where I mean.

Figure 2. Regulations of NPs on the mitophagy and the expressions of pathological proteins. (A) Schematic representation of TPP-rHuHF-LYC nanodots regulating mitophagy. (B) Immunofluorescent staining of the expressions of mitophagy-related proteins in PC12 cells (red: PINK1/Parkin; green: cytoskeleton; blue: nucleus). (C) Statistics of the fluorescence intensity of Parkin and PINK1 proteins. (D) The relative gene expression of Parkin and PINK1 proteins. (E) Expression levels of mitophagy-related proteins via Western blotting analysis.

Figure 4. Regulation of NPs on the PD pathological proteins in dopaminergic neurons and activation of glial cells. (A–D) Representative immunofluorescent staining and quantitative analysis of TH and α-Syn in the dopaminergic neurons of MPTP-treated mice. Scale bars are 25 μm. (E, F) The relative gene expressions of TH and α-Syn in the dopaminergic neurons. (G) Western blotting for the expression of PD pathological proteins.

Figure 5. Enhancement on mitophagy by TPP-rHuHF-LYC nanodots through the PINK1/Parkin-mediated signaling pathway. (A) The protein expressions of PINK1 and Parkin in dopaminergic neurons reflected by immunofluorescent staining. The scale bar is 50 μm. (B) Relative statistics of the fluorescence intensity of Parkin and PINK1 proteins; the difference among groups was statistically significant (p

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来源：学者探讨一点号