摘要：由于miR-301a抑制剂（anti-miR-301a，简称anti-iR）对与炎症性肠病（IBD）病程显著相关的miR-301a具有显著抑制作用，其在IBD治疗中的应用已被广泛探索。然而，anti-iR的口服治疗效果有限，且无法调控炎症结肠中活性氧（ROS）
期刊导读
Journal Guide
1
An anti-miR-301a and zinc coordination driven nanozyme loaded in nanoparticle for oral therapy of inflammatory bowel disease based on colitis microenvironment regulation
由于miR-301a抑制剂（anti-miR-301a，简称anti-iR）对与炎症性肠病（IBD）病程显著相关的miR-301a具有显著抑制作用，其在IBD治疗中的应用已被广泛探索。然而，anti-iR的口服治疗效果有限，且无法调控炎症结肠中活性氧（ROS）和硫化氢（H₂S）的过度表达。在本研究中，基于锌（Zn）配位的辅助优势，我们开发了一种anti-iR与Zn配位驱动的纳米酶（anti-iR−Zn，简称R-Z），可在促进anti-iR转染的同时调控ROS和H₂S。此外，我们还制备了由R-Z和ROS响应脂质体组成的口服纳米颗粒（R-Z@iPS），以克服复杂的胃部环境，并在结肠炎症区域富集。在结肠炎小鼠模型中，R-Z@iPS可通过调控ROS和H₂S减轻结肠炎症指数，修复受损的紧密连接和黏液层。此外，该纳米颗粒可下调miR-301a水平，抑制核因子kappa-B信号通路，并增加Smad核相互作用蛋白1和B细胞易位基因1的表达，从而逆转结肠炎症。R-Z@iPS还可通过增加益生菌丰度、减少有害菌丰度来协调结肠炎微环境，恢复肠道菌群平衡。综上，本研究开发了一种具有良好安全性的新型口服纳米颗粒，在结肠炎的综合临床管理中具有潜力，并可能改变其他miR-301a相关疾病的反义寡核苷酸治疗模式。
（信息以英文摘要为准）
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文章介绍：
上述研究工作的成功实施，主要依托于上海市细胞代谢光遗传学技术前沿科学研究基地，国家重点研发计划，国家自然科学基金，和中央高校基本科研业务费等项目的资助和支持。
期刊介绍
《Chemical Engineering Journal》是 Elsevier 旗下化学工程与环境科学领域的国际权威期刊，2023年影响因子达 15.1，JCR与中科院分区均为 Q1/1区Top期刊，覆盖催化、环境治理、新能源材料、绿色工艺等方向，强调跨学科应用与创新。
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Multiscale Investigation of the interface interactions between humic acid-sulfhydryl grafted palygorskite composites and Cd2+
Multifunctional ruthenium/exfoliated layered metal oxide–graphene oxide nanocomposites for homogeneous base-free oxidation of 5-hydroxymethylfurfural
3D-printed TaSe2/WO3/ZnIn2S4 for increased photocatalytic degradation of rifampicin antibiotic: Role of reactive oxygen species and interfacial charge transfer
Single-layer RGB cholesteric liquid crystals for next-generation full-color reflective displays and advanced anti-counterfeiting
Synergistic modulation of electronic structure in high entropy perovskite oxide for enhanced bifuntional oxygen evolution/reduction reactions and its mechanistic insights via in-situ analyses and density functional theory calculation
Fabrication of a high strength, swelling resistance, and conductive hydrogel for flexible underwater sensor via ketalization
Microstructure evolution of SOFC pure Ni anode with carbon deposition under polarization
Dual-interface induced bandgap regulated water-based flexible interactive generator
A self-reinforcing, self-healing, and shape memory polybutadiene-based polyurethane via disulfide bonds for healable flexible sensors
Manipulating plating mode of bimetallic Cu-Sn and Zn-Sn electrodes for electrochemical denitrification to gaseous nitrogen
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