摘要：Tau蛋白在阿尔茨海默病中可发挥关键作用。阿尔茨海默病的认知能力衰退与 tau蛋白 病变的程度有关，特别是最初出现在跨脑和包括海马在内的大脑相关区域的 tau蛋白 过度磷酸化。
Tau蛋白在阿尔茨海默病中可发挥关键作用。阿尔茨海默病的认知能力衰退与 tau蛋白 病变的程度有关，特别是最初出现在跨脑和包括海马在内的大脑相关区域的 tau蛋白 过度磷酸化。
在正常状态下，Tau蛋白稳定神经微管、促进轴突生长。在阿尔茨海默病的病理状态下，Tau蛋白可出现异常磷酸化和蛋白截断等现象，使其脱离微管、错误折叠、亚细胞错排，导致线粒体损伤、突触功能障碍、胶质增生及神经炎症，终致神经功能退化和认知损缺，从而加速阿尔茨海默病的进展。目前已出现的针对Tau蛋白的治疗策略为阿尔茨海默病预防治疗带来希望。
为此，选择本刊学者2023-2024年发表的Tau蛋白在阿尔茨海默病中的作用研究热点综述文章5篇，推荐读者阅读。
（1）Amyloid-beta and tau protein beyond Alzheimer's disease
阿尔茨海默病之外的淀粉样蛋白β和tau蛋白
Morteza Abyadeh 1, Vivek Gupta 2, Joao A Paulo 3, Arezoo Gohari Mahmoudabad 1, Sina Shadfar 2, Shahab Mirshahvaladi 2, Veer Gupta 4, Christine T O Nguyen 5, David I Finkelstein 6, Yuyi You 2, Paul A Haynes 7, Ghasem H Salekdeh 7, Stuart L Graham 2, Mehdi Mirzaei 2
1 ProGene Technologies Pty Ltd., Sydney, NSW, Australia.
2 Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie Medical School, Macquarie University, Macquarie Park, North Ryde, Sydney, NSW, Australia.
3 Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
4 School of Medicine, Deakin University, Geelong, VIC, Australia.
5 Department of Optometry and Vision Sciences, School of Health Sciences, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne, Parkville, VIC, Australia.
6 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
7 School of Natural Sciences, Macquarie University, Macquarie Park, NSW, Australia.
引用本文：
Abyadeh M, Gupta V, Paulo JA, et al. Amyloid-beta and tau protein beyond Alzheimer's disease. Neural Regen Res. 2024;19(6):1262-1276.
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(2) Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review
阿尔茨海默病发病机制中的 Tau 截断：综述
Dandan Chu 1, Xingyue Yang 2, Jing Wang 2, Yan Zhou 3, Jin-Hua Gu 4, Jin Miao 5, Feng Wu 2, Fei Liu 6
1 Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.
2 Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China.
3 Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, Jiangsu Province, China.
4 Department of Clinical Pharmacy, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong University, Nantong, Jiangsu Province, China.
5 Laboratory of Animal Center, Nantong University, Nantong, Jiangsu Province, China.
6 Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA.
引用本文：Chu D, Yang X, Wang J, et al. Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review. Neural Regen Res. 2024;19(6):1221-1232.
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(3) Targeting tau in Alzheimer's disease: from mechanisms to clinical therapy
以阿尔茨海默病中的 tau 为靶点：从机制到临床治疗
Jinwang Ye 1, Huali Wan 2, Sihua Chen 1, Gong-Ping Liu 3,4
1 Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong Province, China.
2 Department of Laboratory Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China.
3 Co-innovation Center of Neurodegeneration, Nantong University, Nantong, Jiangsu Province, China.
4 Department of PathoPhysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
引用本文：
Ye J, Wan H, Chen S, Liu GP. Targeting tau in Alzheimer's disease: from mechanisms to clinical therapy. Neural Regen Res. 2024;19(7):1489-1498.
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(4) Therapies for Tau-associated neurodegenerative disorders: targeting molecules, synapses, and cells
Tau相关神经退行性疾病的疗法：靶向分子、突触和细胞
Miranda Robbins
1MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge, UK; University of Cambridge, Department of Zoology, Cambridge, UK.
引用本文：
Robbins M. Therapies for Tau-associated neurodegenerative disorders: targeting molecules, synapses, and cells. Neural Regen Res. 2023;18(12):2633-2637.
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(5) Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease?
海马中 tau 与突触长期抑制的相互作用在阿尔茨海默病的进展中起关键作用吗？
Zhengtao Hu 1, Tomas Ondrejcak 2, Pengpeng Yu 3, Yangyang Zhang 3, Yin Yang 4, Igor Klyubin 2, Sean P Kennelly 5, Michael J Rowan 2, Neng-Wei Hu 4
1 Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province; Department of Gerontology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, China.
2 Department of Pharmacology & Therapeutics and Institute of Neuroscience, Trinity College, Dublin, Ireland.
3 Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China.
4Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China; Department of Pharmacology & Therapeutics and Institute of Neuroscience, Trinity College, Dublin, Ireland.
5 Department of Age-Related Healthcare, Tallaght University Hospital; Department of Medical Gerontology, Trinity College, Dublin, Ireland.
引用本文：
Hu Z, Ondrejcak T, Yu P, et al. Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer's disease? Neural Regen Res. 2023;18(6):1213-1219.
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来源：中国神经再生研究杂志
