摘要：在《心血管病探索（英文）》2025年2期中，Minsi Cai和Jordi Heijman（Jordi Heijman为通信作者）发表了题为“心房颤动管理的挑战与机遇”的综述。

在《心血管病探索（英文）》2025年2期中，Minsi Cai和Jordi Heijman（Jordi Heijman为通信作者）发表了题为“心房颤动管理的挑战与机遇”的综述。

心房颤动（房颤）的管理在过去几十年中已取得重大进展。然而，在疾病、患者及人群层面，房颤管理仍面临诸多挑战，包括对可作为临床靶点的基本机制认识不全面、检测方法与治疗手段尚不理想等。近年来，随着对疾病认识的深化，并结合现代监测设备、先进计算模型、新型抗心律失常药物与消融策略的应用，上述问题的解决正成为可能，最终将推动房颤诊断、分类和治疗的范式转变。本文综述了房颤管理领域的关键挑战与未来机遇。

Challenges and Opportunities for Atrial Fibrillation Management

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide and is associated with poor clinical outcomes and a huge economic burden on healthcare systems. Optimized anticoagulation, better symptom control via rhythm or rate control, and comprehensive comorbidity/risk factor management are 3 essential pillars of current AF management, where much progress has been made during the past decades. However, numerous challenges in AF management remain at the disease, patient, and population levels, including an incomplete understanding of basic mechanisms that can be clinically targeted; heterogenous progressive natural history; poor correlation between rhythm and symptoms/outcomes; as well as suboptimal detection methods and treatment options. Recent advances in disease perception in combination with modern monitoring devices, state-of-the art computational models, and novel antiarrhythmic drugs and ablation strategies can contribute to addressing these issues, ultimately leading to a paradigm shift in AF diagnosis, classification, and treatment. This narrative review summarizes these key challenges and future opportunities in the field of AF management.

Keywords: Atrial fibrillation; Anticoagulation; Pathophysiology; Precision medicine; Rhythm control; Translational challenges

Citation: Cai M, Heijman J. Challenges and Opportunities for Atrial Fibrillation Management. Cardiol Discov 2025;5(2):149–161. doi: 10.1097/CD9.0000000000000155

来源：科创中国一点号