MET先锋派 | 创新驱动!卡马替尼推动METex14跳突晚期NSCLC迈向诊疗新阶段

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摘要:Cortot AB, Kherrouche Z, Descarpentries C, et al. Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers. J Natl Ca

参考文献:

[1] Cortot AB, Kherrouche Z, Descarpentries C, et al. Exon 14 Deleted MET Receptor as a New Biomarker and Target in Cancers. J Natl Cancer Inst. 2017;109(5):10.1093/jnci/djw262.

[2] 2024 CSCO非小细胞肺癌诊疗指南.

[3] 中华医学会肿瘤学分会. 中华医学会肺癌临床诊疗指南(2024版)[J]. 中华肿瘤杂志,2024,46(09):805-843.

[4] 中华医学会病理学分会, 国家病理质控中心, 中华医学会肿瘤学分会肺癌学组, 等.非小细胞肺癌MET临床检测中国专家共识 [J] . 中华病理学杂志, 2022, 51(11) : 1094-1103.

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[6] Huang C, Zou Q, Liu H, et al. Management of Non-small Cell Lung Cancer Patients with MET Exon 14 Skipping Mutations. Curr Treat Options Oncol. 2020;21(4):33.

[7] Spigel DR, Edelman MJ, O'Byrne K, et al. Results From the Phase III Randomized Trial of Onartuzumab Plus Erlotinib Versus Erlotinib in Previously Treated Stage IIIB or IV Non-Small-Cell Lung Cancer: METLung. J Clin Oncol. 2017;35(4):412-420.

[8] Catenacci DVT, Tebbutt NC, Davidenko I, et al. Rilotumumab plus epirubicin, cisplatin, and capecitabine as first-line therapy in advanced MET-positive gastric or gastro-oesophageal junction cancer (RILOMET-1): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2017;18(11):1467-1482.

[9] Drilon A, Clark JW, Weiss J, et al. Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration. Nat Med. 2020;26(1):47-51.

[10] Baltschukat S, Engstler BS, Huang A, et al. Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation. Clin Cancer Res. 2019;25(10):3164-3175.

[11] Wolf Jürgen, Hochmair Maximilian, Han Ji-Youn, et al. Capmatinib in MET exon 14-mutated non-small-cell lung cancer: final results from the open-label, phase 2 GEOMETRY mono-1 trial. Lancet Oncol, 2024, 25: 1357-1370.

[12] Paik PK, et al. Real-world outcomes in non-small-cell lung cancer patients with MET Exon 14 skipping mutation and brain metastases treated with capmatinib. Future Oncol. 2023 Jan;19(3):217-228.

[13] Yi-Long Wu, et al. Capmatinib in Chinese adults with EGFR wt, ALK rearrangement negative (ALK-R−), MET exon 14 skipping mutation (METex14), advanced NSCLC: Results from the phase II GEOMETRY-C study. 2022 ESMO AISA, 388P.

[14] Illini O, Fabikan H, Swalduz A, et al. Real-world experience with capmatinib in MET exon 14-mutated non-small cell lung cancer (RECAP): a retrospective analysis from an early access program. Ther Adv Med Oncol. 2022;14:17588359221103206.

[15] 《国家基本医疗保险、工伤保险和生育保险药品目录(2024年)》http://www.nhsa.gov.cn/module/download/downfile.jsp?classid=0&filename=de66e92b7edd4056ac41c0c4d3c011f3.pdf .

[16] 简明处方:https://www.medlive.cn/recommond.php?kyprojectid=1_002094401_1&hash=DaGO1J

撰写:Coco

审校:Axsean

排版:Yian

执行:Aurora

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来源:医脉通肿瘤科

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