摘要：引用文献总计3312篇，最多的频次为8次，排名前三的文献分别是：WorldHealthOrganization2020guidelinesonphysicalactivityandsedentarybehav…
本期体医融合学术研究共检索到英文相关文献139篇，研究热点主要集中在身体活动对冠心病、糖尿病、慢阻肺等疾病的影响及远程运动康复指导的效果等方面。检索结果如下：1）关键词共词分析。提取关键词287个，经过数据清洗后关键词有283个，词频为2及以上的关键词有26个，累计百分比为30.66%，高频关键词为运动、康复、身体活动、中风等，生成可视化知识图谱（见下图）。2）来源期刊分析。涉及期刊65种，其中载文2篇及以上的期刊有8种，累计百分比为32.3%，刊载体医融合前三的期刊为：Scientific Reports（JCR学科分区Q1）、BMC Sports Science Medicine and Rehabilitation（JCR学科分区Q1）、BMJ Open（JCR学科分区Q2）。3）交叉学科分析。引用文献总计3312篇，最多的频次为8次，排名前三的文献分别是：World Health Organization 2020 guidelines on physical activity and sedentary behavior、Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults: Guidance for Prescribing Exercise、Physical Activity and Exercise Recommendations for Stroke Survivors A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association。4）学术关注度分析。文献级别用量最多的是11次，排名前三位的文献分别为：Exploring the exercise experiences of lung transplant recipients during the waiting list period: A qualitative study、Baduanjin Exercise Training for Elderly Chronic Obstructive Pulmonary Disease Patients with Mild Cognitive Impairment: A Feasibility Clinical Trial、Combined network pharmacology and metabolomics reveal that Rubia cordifolia L. ameliorates exhaustive exercise-induced myocardial injury in rats via the BCAA degradation pathway。
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Ahmadi M, Mundell H, Sutherland G, et al. Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank [J]. Journal of Sport and Health Science, 2025, 14.
ABSTRACT :
Background: It is unclear whether physical activity can benefit participants with high genetic predisposition to cardiovascular disease. We examined the joint associations of intensity-specific physical activity and genetic predisposition (based on polygenetic risk score) with incident coronary heart disease (CHD), stroke, and atrial fibrillation (AF). Methods: This prospective cohort study included 303,950 adults (age = 56.4 8.0 years, mean SD; 52.5% females) from the UK Biobank with physical activity and disease-related genotypes. Moderate-to-vigorous physical activity (MVPA) and intensity-specific activity was classified according to volume (e.g., MVPA was classified as none, low, medium, and high). Genetic predisposition for CHD, stroke, and AF were classified as low (Quintile 1), intermediate (Quintiles 2-4), and high (Quintile 5). Results: During 11.6 2.1 years of follow-up: 19,865 CHD, 7907 stroke, and 16,688 AF events occurred. Compared to the no MVPA and high genetic risk group, we observed lower CHD risk for increasing levels of MVPA over and above genetic risk groupings. These associations were primarily driven by vigorous-intensity activity. For example, in the high genetic risk group, those with low vigorous-intensity activity levels (compared to none) had a hazard ratio (HR) of 0.78 (95% confidence interval (95%CI): 0.72-0.86) compared to an HR of 0.92 (95%CI: 0.86-0.99) for low moderate-intensity activity levels. For stroke incidence, we observed a protective association for MVPA across genetic risk groups that was mostly driven by moderate-intensity activity volume. Among the high genetic risk group, low moderate-intensity had an HR of 0.77 (95%CI: 0.66-0.90), whereas low vigorous-intensity had no association (HR = 0.95, 95%CI: 0.82-1.09). We did not observe a consistent joint association of MVPA and AF genetic predisposition. Conclusion: We observed lower CHD and stroke risk for low to high MVPA among participants with high genetic predisposition. The associations of moderate- and vigorous-intensity activity volume differed considerably across cardiovascular disease sub-types. Overall, our findings suggest vigorous-intensity activity may mitigate genetic predisposition for CHD while moderate intensity activity may be associated with similar effects for stroke. Joint associations were less consistent across AF genetic predisposition groups. Our results inform precision medicine approaches and future lifestyle modification interventions by quantifying the potential benefits of physical activity among at-risk individuals.
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Bahls M, Kavousi M, Bakker E, et al. Physical activity and mortality: towards healthspan-oriented metrics and outcomes. A Scientific Statement from the European Association of Preventive Cardiology (EAPC) of the ESC [J]. European Journal of Preventive Cardiology, 2025.
ABSTRACT :
The current guidelines for cardiovascular disease prevention by the European Society of Cardiology highlight the undisputable benefits of exercise and a physically active lifestyle for cardiovascular risk reduction. In addition to the health benefits of physical activity, observational data suggest that regular physical activity lowers all-cause mortality. However, this was not confirmed by Mendelian randomization studies and randomized controlled trials. We argue that limitations of observational data (e.g. recall and recruitment bias, Hawthorne effects, and/or potentially reverse causation) and controlled trials (e.g. healthy volunteer bias and short follow-up) may compromise effects for exercise and physical activity on mortality. In addition, medical care in modern countries guarantees longer survival despite a high incidence for cardiovascular disease, which further reduces the potential impact of exercise and physical activity on lifespan. Healthspan, as a concept, focuses on life years in good health, as opposed to mere lifespan or mortality, which focuses solely on longevity. We propose using different measures of healthspan as an outcome to quantify the effects of exercise and physical activity. We outline the different dimensions of healthspan and how these could be measured at the population level using scalable, reliable, valid, and non-invasive assessments. Specifically, we propose physical function, mental and cognitive health, chronic disease prevention, and quality of life as appropriate measures. These measures may help to better understand physical activity and exercise-related benefits that contribute to a healthier life and to implement interventions that have the potential to increase healthspan across populations.
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Baytok E, Gueclue M, Kol B, et al. Oxygen consumption chronotropic response to maximal exercise and physical activity level in patients with post-COVID-19 and pulmonary involvement [J]. Physiotherapy Theory and Practice, 2025.
ABSTRACT :
Background: Pulmonary involvement due to coronavirus disease 2019 (COVID-19) is common. Pulmonary involvement may affect pulmonary function. Moreover, structural alterations in the lungs may impair the extrapulmonary functions. Purpose: This study compared respiratory functions, peripheral muscle strength, maximal exercise capacity, chronotropic incompetence (CI) (
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Burstein D, Tompkins C, Lansing A, et al. Understanding Pediatrician Perspectives on Physical Activity for Children with Special Health Care Needs [J]. Pediatric Cardiology, 2025.
ABSTRACT :
To assess pediatric clinician knowledge of physical activity recommendations, their approach to physical activity counseling, and their interest in a structured academic fitness program for children and youth with special health care needs (CYSHCN). Electronic questionnaire was developed by cardiovascular, psychology, and exercise physiology collaborators at an academic children's hospital. Regional pediatric clinicians across an urban and rural catchment area were anonymously surveyed. Subgroup differences were assessed using Student's t test, Fisher's exact test, and logistic regression. Survey response rate was 22% (78/351), including 60 general and 18 subspecialty clinicians, half of which (49%) are in rural practice. Over 80% reported general knowledge of physical and psychological benefits of physical activity, although only 49% were aware of specific physical activity recommendations for CYSHCN. Most (90%) perceive that CYSHCN participate in physical activity less than age-matched peers but only 55% routinely discuss physical activity recommendations. Clinicians who report exercising >= 4 days per week are more likely to discuss physical activity with their patients (OR 2.74, 95% CI 1.06-7.13; p = 0.038). Nearly, all (95%) clinicians supported development of a dedicated academic cardiometabolic exercise program for CYSHCN. Clinicians identified time commitment (89%), transportation (84%), insurance (79%), and differing interest levels of patients/families (43%) as potential participation barriers. While most clinicians are aware that physical activity benefits CYSHCN, clinical knowledge gaps exist regarding appropriate recommendations and counseling. Physical activity practices of healthcare professionals may be associated with frequency of patient counseling. Development of structured physical activity programs for CYSHCN should seek to improve knowledge and counseling, include clinicians as physical activity role models, and limit participation barriers.
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Choi Y, Jee H. The protocol for developing health and disease prevention services: An exercise-based prediction model integrating genomic test results [J]. Plos One, 2025, 20(7).
ABSTRACT :
Background: Cancer is a leading cause of mortality worldwide, with approximately 19.6 million new cases and 10 million deaths reported in 2020. Exercise interventions have demonstrated positive effects on physical and mental health in cancer patients, yet there is limited evidence on the efficacy of tailored, high-intensity exercise programs designed using genomic data. This protocol outlines a study aimed at integrating genomic analysis and personalized exercise interventions to improve health outcomes and reduce cancer-related risk factors. This study aims to evaluate the feasibility and potential impact of a personalized exercise intervention delivered through the EXESALUS mobile application. The program integrates genomic information to tailor exercise regimens for cancer prevention, muscle strength improvement, and quality-of-life enhancement. Methods: This is a protocol for a 3-month, parallel-group, randomized controlled trial involving 500 participants, including 100 cancer patients undergoing treatment or rehabilitation and 300 non-cancer participants with elevated disease risk. Participants will engage in the EXESALUS program, which includes low-, moderate-, and high-intensity exercise tailored to genomic profiles, supported by exercise counseling and wearable device feedback. Biospecimens (blood, urine, and oral epithelial cells) will be collected at baseline, 6 weeks, and 3 months to assess genomic variations and physiological changes. Primary outcomes include physical performance (SPPB), muscle strength (1RM and peak power), and skeletal muscle mass (DXA). Secondary outcomes will evaluate mental health indicators such as fatigue (FACIT-F), resilience, anxiety, depression, and quality of life. Discussion: This study will provide a detailed framework for implementing ICT-based personalized exercise interventions that incorporate genomic analysis. The EXESALUS program is expected to highlight the potential of tailored high-intensity exercise as a preventive and therapeutic strategy for cancer patients and individuals at risk of chronic diseases. The findings of this protocol will contribute to the development of precision medicine approaches for cancer prevention and management, emphasizing the scalability and utility of ICT-based solutions in health promotion.
06
Domingues W, Oliveira M, Silva P, et al. Barriers and factors associated with physical activity in patients with chronic venous insufficiency [J]. Phlebology, 2025.
ABSTRACT :
Background: Personal and environmental barriers can make it difficult to engage in physical activity. In people with chronic venous insufficiency (CVI), these barriers may exacerbate physical inactivity, but it is not known whether they are independently associated with physical activity levels in addition to clinical and sociodemographic factors. Objective: To analyze the barriers and factors that are associated with the level of physical activity in patients with CVI. Methods: This cross-sectional study included 97 participants, CVI patients with Clinical-Etiology-Anatomy-Pathology (CEAP) C3 to C6 (69.1% women 58.9 +/- 10.7 years; 51.5% C5-C6 in CEAP classification). Personal and environmental barriers to physical activity were assessed by questionnaire. Objective time spent in physical activity was measured using a triaxial accelerometer. Sociodemographic and clinical characteristics were self-reported. Simple and multiple logistic regression was used to examine the association of age with measures of functional capacity, adjusting for sociodemographic, behavioral, clinical, and anthropometric factors. Statistical significance was accepted at p
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Güven G, Koyuncuoglu N, Çelik A, et al. Upper extremity functional exercise capacity, muscle oxygenation, respiratory muscle strength, and physical activity levels in patients underwent pneumonectomy for lung cancer: a cross-sectional study [J]. Supportive Care in Cancer, 2025, 33(8).
ABSTRACT :
Purpose: Anatomical and physiological changes impair pulmonary function, respiratory muscle strength, and physical activity in patients who underwent pneumonectomy for lung cancer (LC). No study investigated upper extremity exercise capacity and muscle oxygenation in these patients. The main objective of the study was to compare the long-term upper extremity exercise capacity and muscle oxygenation; the secondary objective was to assess pulmonary function, respiratory muscle strength and endurance, and physical activity levels in patients who underwent pneumonectomy for LC and healthy individuals. Methods: Nineteen patients who underwent pneumonectomy for LC and 19 healthy controls were included. Pulmonary function (spirometry), upper extremity functional exercise capacity (6-min pegboard and ring test (6-PBRT)), muscle oxygenation (near-infrared spectroscopy), respiratory muscle strength (maximal inspiratory (MIP) and expiratory (MEP) pressures) and endurance (incremental threshold loading), and physical activity (activity monitor) were evaluated. Results Patients' pulmonary function, 6-PBRT score, muscle oxygen saturation (SmO2), MIP, MEP, and respiratory muscle endurance were lower (p
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Joisten C, Hirschmülier A, Bauer P, et al. Sports Preparticipation Evaluation for Healthy Adults: A Consensus-Based German Guideline [J]. Sports Medicine, 2025, 55(8): 1827-51.
ABSTRACT :
The benefits of physical activity are undisputed. However, adverse events can occur in rare cases, particularly during high-intensity or prolonged exercise. During physical activity, at-risk patients can experience major cardiac events, whereas adverse events affecting the musculoskeletal system are more common but less severe. A sports preparticipation evaluation (PPE) for apparently healthy adults is designed to detect at-risk individuals and prevent potentially fatal events. This guideline for conducting PPEs was developed by consensus among 16 medical societies and sports associations and is based on previously published guidelines and consensus papers. Sports medicine physicians and potential participants were also surveyed to assess the recommendations' content, feasibility, and implementation. On the basis of the 20 recommendations developed and agreed upon by the abovementioned entities, PPE comprises individuals' personal, family, and sports histories, as well as a physical examination. The need for additional examinations (e.g., laboratory parameters, echocardiograms, or stress tests) is determined on the basis of the PPE findings. This approach's feasibility in various regions, including resource-limited settings, and the extent to which it prevents adverse or potentially fatal events, should be examined in future research.
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Keating S, Wilkinson S, Macdonald G, et al. Exercise preion in the management of chronic disease falling through an evidence-practice gap: Perspectives of doctors and nurses in specialist settings [J]. Journal of Health Services Research & Policy, 2025, 30(4): 270-81.
ABSTRACT :
Objectives: Exercise is a frontline therapy for the management of chronic cardiometabolic disease, however traditional tertiary health care service models do not include exercise physiology. We aimed to explore professional roles, practices, and services regarding exercise care in chronic cardiometabolic disease from the perspectives of specialist doctors and nurses. Methods: Using a qualitative deion design, semi-structured individual interviews were conducted with 32 doctors and 26 nurses involved in the care of relevant patients with liver, kidney, or cardiac disease, or diabetes, across hospital and community settings in a Queensland metropolitan health service. Interviews were audio-recorded, transcribed verbatim and analysed using thematic analysis. Results: Four overarching themes were identified. Despite universal acceptance of the multifactorial benefits of exercise, there was a lack of confidence in patients' capabilities to exercise and safety concerns due to complex comorbidities. Interviewees considered themselves 'promotors not prescribers' of exercise. There was no structured exercise history taken outside of cardiac rehabilitation units with significant variability in advice provided. Access to exercise specialist services was limited and disease-specific, with inconsistent and fragmented referral pathways. General Practitioners were considered responsible for facilitating exercise specialist involvement in ongoing care, with onus placed on patients to initiate. Conclusions: There is an evidence-practice gap between the established benefits of exercise for chronic disease management and access to exercise professionals and services, resources, and knowledge. This deprioritises exercise as a frontline therapy with patient care implications. This study identified a need to transform the way that exercise care is accessed and delivered in tertiary settings.
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Kim H, Park S, Oh Y, et al. Changes in physical activity before and after the diagnosis of dyslipidemia and the risk of atrial fibrillation: a population-based study in South Korea [J]. Preventive Medicine Reports, 2025, 57.
ABSTRACT :
Objective: While physical activity is known to influence atrial fibrillation risk in the general population, evidence is limited among patients newly diagnosed with dyslipidemia. This study aimed to evaluate the association between changes in physical activity before and after dyslipidemia diagnosis and atrial fibrillation risk. Methods: Using the Korean National Health Insurance Service database, we identified 441,509 Korean adults newly diagnosed with dyslipidemia between 2011 and 2015, free of atrial fibrillation at baseline and with complete data. Metabolic equivalent tasks (METs)-min/week were calculated before and after dyslipidemia diagnosis. Participants were followed up until atrial fibrillation, death, or December 31, 2021. Results: During 3,164,996 person-years of follow-up, 6003 patients developed atrial fibrillation. Increasing physical activity from inactive to >= 1000 MET-min/week was associated with reduced atrial fibrillation risk (adjusted hazard ratio [aHR], 0.85; 95 % confidence interval [CI], 0.81-0.90), compared with inactive. Conversely, decreasing physical activity from >= 1000 MET-min/week to inactive was associated with increased atrial fibrillation risk (aHR, 1.23; 95 % CI, 1.15-1.31). These results were consistent regardless of statin use, hypoalphalipoproteinemia, and hyperlipidemia status. Conclusions: Encouraging newly diagnosed dyslipidemia patients to increase their physical activity levels may help reduce their risk of atrial fibrillation.
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Kyriakoulakou E, Skouras A, Tsolakis C, et al. Knowledge and Education on Physical Activity Health Benefits and Preion Principles Among Greek Medical Students [J]. Behavioral Sciences, 2025, 15(7).
来源：京津冀消息通
