摘要：Professor He Xiaoshun's team at the First Affiliated Hospital, Sun Yat-sen University, pioneered the ischemia-free organ transplan

Recently, Professor He Jianxing's team at the First Affiliated Hospital of Guangzhou Medical University successfully transplanted a lung from a genetically modified pig into a brain-dead recipient and maintained normal ventilation for nine days. The results were published in the journal "Nature Medicine" and hailed by the international scientific community as a "milestone in xenotransplantation."

Professor He Jianxing from the First Affiliated Hospital of Guangzhou Medical University

Professor He's team employed the "tubeless" technology in lung transplantation to complete in four hours what traditionally takes six to eight hours, pioneering a new approach to multi-organ transplantation. They have completed a total of 829 lung transplantations and 22 combined heart-lung transplantations. The recent transplantation of a gene-edited pig lung (knocking out genes related to immune rejection) marks a transition of xenogeneic lung transplantation from "theoretically feasible" to "clinical trials."

Professor He Xiaoshun's team at the First Affiliated Hospital, Sun Yat-sen University, pioneered the ischemia-free organ transplantation (IFOT) technology, providing oxygen and blood to ex vivo organs through machine perfusion, overcoming the challenges of ischemia–reperfusion injury. Their findings were published in international journals. The approach to organ preservation ex vivo even enabled a pig's head to blink and breathe after being detached, offering new strategies for cardiac arrest resuscitation.

Ischemia-free liver transplantation surgical team of the First Affiliated Hospital of Sun Yat-sen University

Guangdong has never ceased exploring organ transplantation. In 2003, Shenzhen in Guangdong province introduced the country's first regulations on organ donation. In 2011, the province established China's first Organ Procurement Organization (OPO). Today, Guangdong has 21 organ transplantation medical institutions, the most in the country, with leading kidney and liver transplant volumes. Its heart and lung transplant techniques are internationally advanced, and for 13 consecutive years, it has ranked first nationally in deceased organ donations, with cumulative donations accounting for more than one-fifth of the national total.

从基因编辑猪肺移植，看广东器官移植的探索之路

近日，广州医科大学附属第一医院何建行教授团队，将基因编辑猪肺移植到脑死亡人体内并实现9天正常通气，成果登上《自然-医学》，获国际学界“异种移植里程碑”评价。

何建行团队采用“无管肺移植”技术4小时完成传统6-8小时手术，开创多器官联合移植新方式，累计完成829例肺移植、22例心肺联合移植，此次基因编辑猪肺（敲除免疫排斥基因）移植，让异种肺移植从“理论可行”迈向“临床可期”。

中山大学附属第一医院何晓顺教授团队首创“无缺血”器官移植技术，用机械灌注为离体器官供氧供血，破解缺血损伤难题，相关成果登上国际期刊，其“离体器官养护技术”还实现猪头离体后眨眼、呼吸，为心跳骤停抢救提供新策略。

广东在器官移植上的探索从未止步。2003年深圳出台全国首部器官捐献法规，2011年建国内首家器官获取组织（OPO），现全省21家器官移植医疗机构数量居全国之首，肾、肝移植规模领跑，心、肺移植技术达国际一流，且连续13年遗体器官捐献量全国第一，累计捐献量占全国1/5以上。

文｜记者 张华 陈辉 王沫依

图｜受访者提供

统筹｜张华

翻译 | 曾敏

审校 | 肖凯欣

来源：羊城派