摘要：诺奖得主代表了人类智慧与科学发展的高度。他们的价值不仅在于个人取得的卓越成就，更在于他们对社会的深远影响和伟大贡献！诺奖得主是人类智慧的灯塔，他们以无畏的探索精神和深邃的洞察力，引领世界走向更美好的未来！
*附英文版本
English version attached
诺奖得主代表了人类智慧与科学发展的高度。他们的价值不仅在于个人取得的卓越成就，更在于他们对社会的深远影响和伟大贡献！诺奖得主是人类智慧的灯塔，他们以无畏的探索精神和深邃的洞察力，引领世界走向更美好的未来！
京领作为创新驱动的诺奖创新平台、全球院士平台、国际标准平台，始终尊重学术、尊重学者、尊重教育。京领每年举办诺奖创新论坛，先后邀请诺贝尔经济学奖得主、诺贝尔物理学奖得主、诺贝尔化学奖得主、诺贝尔生理学或医学奖得主与全球数百所国际化学校及优秀学子共同参与，旨在汇聚全球创新智慧，推动教育质量提升、科技产业升级、社会创新发展，培养面向未来的创新人才！
京领诺奖创新论坛为全球学子提供了与诺奖得主交流的平台，让世界顶尖科学家与“未来科学家”对话，以科学精神引领青少年创新思维升级，激发青少年创新热情，培养下一代诺奖科学家！用教育改变世界，用人才创造未来！
今年，京领诺奖创新论坛暨全球国际学校颁奖典礼将于北京时间2025年3月29日在国家会议中心举行。届时，3位诺贝尔奖得主将作为嘉宾致辞，并与全球国际学校优秀学子互动交流！
诺贝尔经济学奖得主
诺贝尔化学奖得主
诺贝尔生理学或医学奖得主
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历年诺奖得主嘉宾
Previous Nobel Laureates Speakers
作为人类智慧与科学发展高度的代表，来自美国藤校等世界名校的多位诺贝尔奖得主，包括诺贝尔经济学奖得主、诺贝尔物理学奖得主、诺贝尔化学奖得主、诺贝尔生理学或医学奖得主等，曾多次参与京领论坛。
历年诺奖论坛嘉宾
诺贝尔经济学奖得主Maskin院士
诺贝尔经济学奖得主
哈佛大学最高级别教授——校级教授
哈佛大学经济学与数学终身正教授
美国国家科学院院士
美国艺术与科学院院士
• 哈佛大学校级教授——哈佛大学最高荣誉
• 诺贝尔经济学奖获奖成果：机制设计理论
• 在诺贝尔奖得主、知名经济学家肯尼斯·阿罗指导下，26岁时获得哈佛大学博士学位
• 31岁成为麻省理工学院最年轻终身正教授之一
• 57岁获得诺贝尔经济学奖
• 培养出两名诺奖得主：2014年诺贝尔经济学奖得主让·梯诺尔，2019年诺贝尔经济学奖得主班纳吉
历年诺奖论坛嘉宾
诺贝尔生理学或医学奖得主Kaelin院士
诺贝尔生理学或医学奖得主
哈佛大学医学终身讲席教授
美国国家科学院院士
美国艺术与科学院院士
美国国家医学院院士
• 诺贝尔生理学或医学奖获奖成果：“细胞氧气感知通路”，为癌症治疗提供了新的视角和思路，具有深远的影响力
• 美国最具声望的生物医学奖——拉斯克奖得主
• 制定“凯林十诫”研究准则，彰显了他对科研诚信和卓越精神的深切信念
历年诺奖论坛嘉宾
诺贝尔化学奖得主Kornberg院士
诺贝尔化学奖得主
斯坦福大学终身讲席教授
美国国家科学院院士
美国艺术与科学院院士
• 诺贝尔化学奖获奖成果：真核转录的分子基础
• 其父是诺贝尔生理学或医学奖得主亚瑟·科恩伯格
• 美国最高化学奖——韦尔奇奖得主
• 法国科学院生物医学科学最高奖得主
• 20岁哈佛大学本科毕业，25岁获得斯坦福大学博士学位
历年诺奖论坛嘉宾
诺贝尔物理学奖得主Barish院士
诺贝尔物理学奖得主
美国国家科学院院士
美国艺术与科学院院士
• “引力波”之父，量子医学的划时代奠基人
• 诺贝尔物理学奖获奖成果：LIGO探测器和引力波观测
• 验证爱因斯坦100年前对引力波的预测
• 美国加州理工学院荣休教授
• 26岁获得加州大学伯克利分校博士学位
历年诺奖论坛嘉宾
诺贝尔生理或医学奖得主Schekman院士
诺贝尔生理或医学奖得主
美国国家科学院院刊前主编
美国国家科学院院士
美国艺术与科学院院士
• 诺贝尔生理学或医学奖获奖成果：细胞膜囊泡运输
• 曾任美国国家科学院院刊主编
• 美国最具声望的生物医学奖——拉斯克奖得主
• 在诺贝尔生理学或医学奖得主亚瑟·科恩伯格指导下获得斯坦福大学博士学位
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往届诺奖对话精彩回顾
Highlights of Previous Dialogues with Nobel Laureates
以下为部分优秀学子代表在2024年京领诺奖创新论坛与诺贝尔生理学或医学奖得主、哈佛大学终身讲席教授Kaelin院士的精彩互动。
北京师范大学附属实验中学国际部优秀学子
Jiayi Chen
什么改变了您对生物学的兴趣？数学思维对医学研究有什么帮助？
我的第一爱好是数学和计算机科学。当我上高中的时候，我被选中去一所大学，和来自美国各地的其他31名高中生一起学习大学水平的数学和计算机科学。但我发现至少有别的学生表现出来的数学天赋比我更高，所以我认为这类人会继续从事最高水平的数学研究。这就是我开始转向医学的原因。但我要说的是，数学是一个很好的方法帮助你学会如何有逻辑地、清晰地、批判性地思考。
北京一零一中国际部优秀学子
Anyuan Zhong
在正常缺氧条件下，EGLN-pVHL通路通过抑制RIPK1促进细胞存活，而在缺氧条件下则引发坏死和炎症，您认为长期缺氧如何影响EGLN-pVHL通路的双重作用？这种平衡是否能为治疗策略提供见解，从而有选择性地操纵这一通路，在肾细胞癌等疾病和其他对缺氧敏感的病症中最大限度地减少炎症？
这是一个非常复杂和精细的问题，需要一系列精密的实验来探究。针对RIPK1确实存在一个矛盾现象，即在失去VHL蛋白的情况下，它应该在缺氧的肿瘤细胞中呈现活跃状态，并对抑制肿瘤起效。我也可以提出一系列的假设来解释他们为什么没有如预期那样表现，但这很复杂。有时在科学研究中，我们需要后退一步，从更简单的问题开始，并以此设计实验，从而积累解决复杂问题的能力。
北京中学国际部优秀学子 Han Gao
在进行生物学研究时，您认为年轻科学家需要具备哪些素养？
首先是发展科学直觉，或是科学品味。科学家需要学会挑选有价值的问题来解决，并设计有效的实验。再而是需要和卓越的科学家们接触，了解他们的思路，寻求他们的帮助。向他们学习在挑选问题和设计有效实验的过程中，如何做到适度的控制并寻求确切的佐证来支持你的结论。最后是驱动力。科学研究是一项艰苦的工作，你必须坚持不懈、不断追求，才有可能获得令人难以置信的回报。
北京四中国际校区优秀学子 Siyi He
我们都知道癌症治疗可以挽救生命，但由于专利保护、科研经费及制药成本等对经济条件的要求，贫穷的国家不一定能负担得了。您如何看待这一现象？
我们现在确实面临着新药开发的成本问题。这是一项昂贵的工作，因为我们的医学和生物学知识还不够完善，所以在猜测和验证的过程中常常需要为失败付出代价。同时，市场对成功率的判断会影响药物研发的进程。因此，我们会希望有越来越多对生物学和人类疾病了解或感兴趣的人加入，降低药物研发的成本，从而让更多人获得帮助。
北京大学附属中学道尔顿学院优秀学子
Jingxuan Cui
您对氧传感途径的研究揭示了与癌症进程有关的基础生物过程。从社会科学角度而言，您如何看待将基础科学发现转化为临床干预措施的伦理意义，特别是在医疗资源的可及性、可负担性和公平分配方面？
作为科学家，我们所能做的就是努力消除开发新药过程中的许多猜测，从而使发现和开发这些药物的成本持续下降。此外，从历史经验而言，一个行之有效的方法是结合市场的集体智慧，即综合地考虑哪些想法有价值，哪些能力值得被鼓励等。
首都师范大学附属中学国际部优秀学子
Yuqi Wang
在医学领域从事抗癌研究的过程中，您是否感到过特别孤独，或处于迷茫、无助和焦虑之中？如果有，您是如何克服这些困难，进行学术探索的？
在最终建立自己的实验室前，我曾作为实习生在三个实验室工作。在第一个实验室时，我获得过一个很糟糕的分数，并觉得自己再也不应该在实验室工作了。第二个实验室好一些，但我当时还未立志要成为一名科学家。第三个实验室是一个很棒的实验室，有一位经验丰富且成果颇丰的导师。但即便如此。我依旧有至少五次和教授说想辞职。科研一定会经历起伏和绝望，或是失去信心的时刻，所以一个健康的研究氛围非常重要。且有时候重要的发现是从意想不到的结果开始的，直到人们扩展他们的思维来思考这些结果实际上可能意味着什么。
北京市人朝分实验学校优秀学子
Chunsu Wang
在探索氧传感途径的过程中，您经历过哪些最令人沮丧的时刻？对于克服这些学术道路上的挫折，您有何建议？
当我们非常接近最终获得诺贝尔奖的成果时，我们发现 HIF 转录因子正在经历一种依赖氧化剂的翻译后修饰。我们知道这种修饰不是磷酸化，并且已经将被修饰的蛋白质缩小到了一个具体的区域范围。在某个后半夜，其他研究人员发现实验室的首席科学家打算窃取实验室的所有数据、试剂等离开了。我们不得不召开紧急会议，重新制作试剂并重做实验。就像这样，挫折是科研的一部分。有时候实验在技术上无法实现、正确的答案是令人失望的。但我认为最重要的一点是，即使没有成功，或者成功的微不足道，也要去庆祝，同时希望大家所处的环境可以感受到导师给予的支持与肯定。
北京市新英才学校优秀学子
Yutong Zhang
是否有可能通过调节上游DNA或调节因子治愈所有癌症？类似的方法能否用于治疗自身免疫性疾病？
一些关键的转录因子和上游调节因子在细胞生物学中非常重要，但我认为它们中的任何一种都无法成为治疗癌症的通用方式。可能产生最广泛作用的是中间转录因子，它在许多癌症研究中都起关键作用。此外，探究此问题时遗传学具有很好的指导作用。如果你有证据表明某一特定基因的改变与某一特定疾病或某一特定表型有关，那么通常可以基于此找到新的药物靶点。几乎所有的癌症都来自于特定的突变，但基于不同的基因，所以很难有普适的方法。自身免疫性疾病也是如此，某些基因明确地影响了免疫系统的活动，它们便是治疗自身免疫性疾病的良好靶点。
上海领科双语学校优秀学子
Chenyu Liang
您认为应该如何培养学生成为更卓越的全球公民和生物学研究者？
我认为医学的未来从未如此光明过。仔细想想，我们在2000年才真正第一次草拟出人类基因组。在过去的十年里，我们才拥有了像酶分析仪这样的工具，开始真正精确地重写基因组代码，以更详细地研究各种基因、各种途径的功能。实验室里，模型变得更专业、工具也变得更高级。因此，就研究人类疾病的能力而言，我们正处于一个全新的时代。但作为一名科学家，最重要的是自己需要找到真正充满热情的研究方向，这是不被外力所影响的。此外，一些卓越且友好的导师，在前沿实验室的工作经历，及扎实的生物学知识缺一不可。然后就可以开始期待神奇事情的发生了。
深圳中学国际部优秀学子 Anzhuo Chen
一个有价值的研究问题是如何诞生的？
有价值的问题有时是从一个非常奇怪的现象开始的，不管是一个生物现象，还是一个临床医学现象。它们像有趣的谜题，而科研的美妙之处在于我可以准确地选择我想要解决的谜题。世界运转的过程中不断发生着令人兴奋的事情，在我们解决难题的过程中又会遇到新的东西，我们可以借此延展，不断发问。当我们成为第一个理解大自然规律的人时，是非常欣喜且有成就感的。
2025京领诺奖创新论坛
诺奖对话面向全球优秀学子开放
2025 KingLead Nobel Innovation Forum
Dialogue with Nobel Laureates is open to outstanding students world-wide
2025京领诺奖创新论坛“诺奖对话”现面向具备社会责任感、有志于投身于创新、有志于成为未来诺奖科学家的全球优秀青少年学子免费开放申请。届时三名诺奖得主，诺贝尔经济学奖得主、诺贝尔化学奖得主、诺贝尔生理学或医学奖得主将与优秀学子对话。每位优秀学子可以根据自身未来发展方向选择一名诺奖得主，并亲自向诺奖得主就学术、教育、创新等前沿领域提出一个有价值的问题，与诺奖得主展开互动。
2025诺奖对话安排
日期：2025年3月29日上午
地点：国家会议中心
08:40-09:10
诺贝尔经济学奖得主对话
面向有意向在经济、金融、数学、社会科学等领域发展的优秀学子
10人
09:20-09:50
诺贝尔化学奖得主对话
面向有意向在化学、有机化学、材料科学等领域发展的优秀学子
10人
10:40-11:10
诺贝尔生理学或医学奖得主对话
面向有意向在生物、医学、健康、脑科学、神经科学等领域发展的优秀学子
10人
诺奖对话结束后，每位成功参与对话的学子将在论坛现场登台获颁诺奖创新平台荣誉证书。
申请流程
每位申请者需要如实填写报名信息并提交英文简历。名额有限，额满即止。有意向参与的学子】申请。
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2025年2月28日 申请截止
申请截止。诺奖创新平台委员会审核材料
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2025年3月5日 通知结果
短信和邮件通知申请结果，入选者回复确认
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2025年3月10日 提交问题
学生提交英文问题，委员会审核
4
2025年3月21日 行前事项
委员会通知学生对话顺序、注意事项等
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2025年3月29日 诺奖对话
学生提前15分钟到场，按顺序进行诺奖对话
现场登台获颁诺奖创新平台荣誉证书
京领诺奖创新论坛诺奖对话环节
学生申请入口
面向全球优秀学子免费开放
申请截止日期：2025年2月28日
English Version
Nobel Laureates represent the peak of human wisdom and scientific development. Their value lies not only in their outstanding personal achievements but also in their profound influence and great contributions to society! Nobel Laureates are the beacon of human wisdom. With their fearless spirit of exploration and profound insight, they lead the world towards a better future!
KingLead, as an innovation-driven Nobel Innovation Platform, a Global Academician Platform, and an International Standard Platform, always respects academics, scholars, and education. KingLead holds the Nobel Innovation Forum annually, inviting Nobel Laureates in Economic Sciences, Physics, Chemistry, and Physiology or Medicine to engage with hundreds of international schools and outstanding students worldwide. The forum aims to gather global innovative wisdom, promote improving education quality, enhance scientific and technological industrial upgrading, drive social innovation progress, and cultivate international innovative talents for the future!
2024 Nobel Innovation Forum Recap
京领新国际
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The KingLead Nobel Innovation Forum provides global students with opportunities and platforms to communicate with Nobel Laureates, to engage the world's top scientists in dialogue with "future scientists", to infiltrate the spirit of science to elevate youth's innovative thinking, to stimulate their enthusiasm for scientific research, and to inspire the next generation of Nobel scientists! Education changes the world, while talents create the future.
This year, The 2025 KingLead Nobel Innovation Forum and the Award Ceremony of Global International Schools will be held at the China National Convention Center on March 29, 2025, Beijing time. Three Nobel Laureates will give speeches and interact with outstanding students from international schools worldwide!
Nobel Laureate in Economics Sciences
Nobel Laureate in Chemistry
Nobel Laureate in Physiology or Medicine
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As the representatives the peak of human wisdom and scientific development, many Nobel Laureates from Ivy League and world-renowned universities, including Nobel Laureates in Economics, Physics, Chemistry, Physiology or Medicine, have participated in the KingLead Forums multiple times.
Previous Nobel Innovation Forum Speaker
Nobel Laureate in Economics Sciences
Professor Maskin
Nobel Laureate in Economic Sciences
University Professor at Harvard University
Professor of Economics and Mathematics at Harvard University
Member of the National Academy of Sciences
Member of the American Academy of Arts and Sciences
• University Professor at Harvard University—the highest honor
• Was awarded the Nobel Prize for his achievements in the theory of mechanism design
• Earned Ph.D. from Harvard University at the age of 26 under the guidence of Nobel Laureate Kenneth Arrow
• Became one of the youngest full professors at MIT at the age of 31
• Was awarded the Nobel Prize at the age of 57
• Two of his students have also won the Nobel Prize:
- Jean Tirole, the 2014 Nobel Laureate in Economics
- Abhijit Banerjee, the 2019 Nobel Laureate in Economics
Nobel Laureate in Physiology or Medicine
Professor Kaelin
Nobel Laureate in Physiology or Medicine
Chaired Professor of Medicine at Harvard University
Member of the National Academy of Sciences
Member of the American Academy of Arts and Sciences
Member of the National Academy of Medicine
• Was awarded the Nobel Prize for the discoveries of how cells sense and adapt to oxygen availability, which lead to new insights and ideas on cancer treatment with profound implications
• Was awarded the Albert Lasker Award—the most prestigious biomedical award in the U.S.
• Established the "Kaelin Ten Commandments" research guidelines, demonstrating his core principles of scientific integrity and excellence
Nobel Laureate in Chemistry
Professor Kornberg
Nobel Laureate in Chemistry
Chaired Professor at Stanford University
Member of the National Academy of Sciences
Member of the American Academy of Arts and Sciences
• Was awarded the Nobel Prize for his studies of the molecular basis of eukaryotic transcription
• Nobel Laureate in Physiology or Medicine--Arthur Kornberg is his father
• Was awarded the Welch Prize—the most prestigious chemistry award in the U.S.
• Was awarded Leopold Mayer Prize—the most prestigious biomedical sciences award of the French Academy of Sciences
• Earned B.A. from Harvard University at the age of 20, and Ph.D. from Stanford University at the age of 25
Nobel Laureate in Physics
Professor Barish
Nobel Laureate in Physics
Member of the National Academy of Sciences
Member of the American Academy of Arts and Sciences
• The father of "gravitational waves", the epoch-making founder of quantum medicine
• Was awarded the Nobel Prize for the decisive contributions to the LIGO detector and gravitational wave detection
• Directly verifying Einstein's 100-year prediction of gravitational waves
• An honorary professor of California Institute of Technology
• Earned Ph.D. from University of California, Berkeley at the age of 26
Nobel Laureate in Physiology or Medicine
Professor Schekman
Former Editor-in-Chief of Proceedings of the National Academy of Sciences
Member of the National Academy of Sciences
Member of the American Academy of Arts and Sciences
• Was awarded the Nobel Prize for the discoveries of machinery regulating vesicle traffic, a major transport system in our cells
• Was the former Editor-in-Chief of Proceedings of the National Academy of Sciences
• Was awarded the Albert Lasker Award—the most prestigious biomedical award in the U.S.
• Earned Ph.D. under the guidence of Nobel Laureate Arthur Kornberg from Stanford University
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Highlights of Previous Dialogues with
the Nobel Laureate
Below are some fancinating interactions between outstanding students representatives and the Nobel Laureate in Physiology or Medicine, chaired professor at Harvard University, Professor Kaelin at the 2024 KingLead Nobel Innovation Forum.
SDSZ International Department Jiayi Chen
What is it that shifted your interest to biology? How may a mathematical mindset be helpful in medical research?
My first love was mathematics and computer science. When I was in high school, I was selected to go to a college and study college-level mathematics and computer science with 31 other high school students from across America. But I did discover there was at least 1 student who was a much better mathematician than I was. So I assume that would be the type of person who would go on to do mathematics at the highest level. That's why I shifted my interest to medicine. But I will say that mathematics is a great way to help you learn how to think logically, clearly and critically.
Beijing 101 Middle School International Department Anyuan Zhong
How might prolonged hypoxia influence the dual role of the EGLN–pVHL pathway in both promoting cell survival through suppression of RIPK1 under normoxic conditions, and triggering necroptosis and inflammation under hypoxic conditions? Could elucidating this balance provide insights into therapeutic strategies that could selectively manipulate this pathway to target cancer cells while minimizing inflammation in diseases like renal cell carcinoma and other hypoxia-sensitive pathologies?
This is a very sophisticated question, and frankly, much more sophisticated than anything I could have come up with when I was your age... To me, the bigger paradox is, at least based on what we currently know about, RIPK1, the kinase you mentioned, it should be active in hypoxia tumor cells, and it should be particularly active in kidney cancers, because they've lost the VHL protein... And I can come up with some hypotheses as to why they're not dying. And each of those hypotheses, I could reduce, I think, to something testable in the laboratory... But sometimes it's good to just step back and see if you can come up with a simpler question that lends itself, hopefully to a simple set of experiments.
Beijing Academy International Division Han Gao
What qualities of young scientists that you think are the most important when conducting research in biological science?
Firstly, the important part of science is developing scientific intuition or scientific taste. Scientists need to pick good problems to work on, and then to design hopefully effective experiments that will begin to generate knowledge related to those questions. Secondly, I think the more important thing is to be around great scientists to see how they think. Because some of that will rub off on you and for them to help you as you learn the process of picking questions and designing effective experiments, complete with appropriate controls and appropriate corroborating lines of evidence to support your conclusion. Lastly, I think you have to hopefully have some drive. Scientific research can be hard work, but it can also be incredibly rewarding if you are persistent in pursuing your ideas.
Beijing No.4 High School International Campus Siyi He
We all know that cancer treatment saves lives, but it is expensive due to patent protection to reward researchers and pharmaceutical companies. So how should it be affordable for poor countries? Should it be cheaper for poor people?
One problem we have now is that developing new treatments, such as new drugs, is extremely expensive. It's partly expensive because our knowledge of medicine and biology is incomplete. So there's a lot of guesswork related to developing new drugs. And as a result, there are many failures, and so every time there is a success, you're also paying for all of the failures along the way... I still fall back on letting the marketplace collectively decide which ideas are worthy of investments... I think collectively, we all have to work better to drive down the cost of developing drugs, which will secondarily and ultimately lead to decrease at the cost. And finally, drugs do eventually go off in price at which point they can be much more broadly available.
The Affiliated High School of Peking University's Dalton Academy Jingxuan Cui
Your research on oxygen sensing pathways has shed light on fundamental biological processes implicated in cancer progression. From a social science perspective, how do you see the ethical implications of translating basic science discoveries into clinical interventions, particularly in terms of accessibility, affordability, and equitable distribution of healthcare resources?
What we, as scientists can do is try to drive much of the guesswork out of developing new drugs so that the cost of discovering and developing those drugs will continue to fall... But I think historically, one system that has worked is to let the collective wisdom of the marketplace decide what are the best ideas and which ideas are most worthy of funding.
Capital Normal University High School
Yuqi Wang
May I ask if conducting anti-cancer research in the medical field has left you feeling particularly lonely or at a time of confusion, helplessness, and anxiety? If so, how did you overcome these difficulties and pursue academic exploration?
I worked in three laboratories as a trainee before. I eventually started my own laboratory. In the first laboratory, my professor gave me a terrible grade and said, I should never work in a laboratory again. The second laboratory was better, but I certainly didn't leave it thinking I was going to be a scientist. Fortunately, for me, the third laboratory was a lot wonderful laboratory with a wonderful mentor who had a long history of training successful young scientist... and there were at least 4 or 5 times when I walked into my professor's office and said, I'm gonna quit... Because we all have ups and downs and moments of despair or moments where we're losing self confidence... A healthy lab is one where we're only seeking the truth. There are no bad results, and frankly, some of the most important discoveries start with unexpected results. When in some cases were disappointing results until people expanded their minds to think about what those results might actually mean.
RCF Experimental School Chunsu Wang
What has been the most frustrating moments during the exploration of oxygen-sensing pathway you have experienced? and what would your suggestions be for overcoming these frustrations in the academic path?
When we were very close to the discovery that eventually led to the nobel prize, we knew that the HIF transcription factor was undergoing an oxidant dependent post translation modification. We knew that it wasn't phosphorylation. We had narrowed down the region of the protein that was modified. And then in the middle of the night, they saw the lead scientist in my lab who was doing this work for reasons, only known to him decided to steal all of the data and notebooks and reagents from my laboratory and go back to his home country... We had to have an emergency meeting in the laboratory so that different people in the laboratory could remake the reagents and re-do the experiments and get us back on our way... But I'm more broadly, frustration is part of this business. Sometimes it's because, as just was said, sometimes maybe experiments aren't working technically or the correct answers, even though correct are somewhat disappointing. I think it's very important that no success, even little success goes on celebrated, and that hopefully you're in an environment where you feel like you're being supported by your mentor.
Beijing New Talent Academy Yutong Zhang
Is it possible to cure all cancers by regulating the upstream DNA or regulatory factors? Can the similar method be used in treating autoimmune diseases?
There are certain key transcription factors and upstream regulators that are very important in cell biology. But I think it's extremely unlikely that any one of them will be a universal target in cancer. I think the closest we might come to that is the mid transcription factor, which is important in many cancers... When in doubt, genetics is a very good guide. And if you have evidence that alteration of a particular gene is linked to a particular disease or a particular phenotype. That's a very good place to start, not only to learn the underlying biology, but it often can lead us to new drug targets as it did with VHL and kidney cancer.
Almost all cancers have certain mutations that have enabled them to be cancers. So they're telling us which genes they care most deeply about. But as you probably also know, for most cancers, it's different genes, and that's why I doubt there will be a universal answer for all cancers. And I will also say when it comes to autoimmune disease, the same rules apply that it turns out there are certain genes that unequivocally dial up or down the activity of the immune system. And those are often proving to be good targets for autoimmune diseases.
Shanghai Ulink Bilingual School Chenyu Liang
How to cultivate students to become more exceptional global citizens and researchers in biology?
I think the future of medicine has never been brighter. When you think about it, we really only had the first draft of the human genome in the year 2000. And we really only had tools like an enzyme analyzer in the past decade to start to really precisely rewrite the genome code to study in more detail what the functions were of various genes and various pathways. In the laboratory, the models have gotten better, and the tools have gotten better. So I think we're in a completely new era in terms of our ability to study human diseases. But the last thing I'll say is being a scientist is about finding the thing that excites you. The thing that you're so passionate about, and this should be dictated from the outside. Hopefully, along the way you meet some good mentors, you're in some good laboratories, you get exposed to some in biology, and then the magic happens.
Shenzhen Middle School International Department Anzhuo Chen
How can I come up with a more essential question?
A good problem sometimes just starts with a very curious phenomenon. Whether it's a biological phenomenon or it's a phenomenon in clinical medicine that strikes you as an interesting puzzle. The beauty of scientific research is that I get to choose exactly what puzzles I want to work on. What makes the world go around is we all find different, interesting and exciting things. As we've been solving these puzzles once in a while, we see something new. Then, we can keep asking questions. When we're the first people in the history of homo sapiens to understand the laws of nature, it is very enjoyable and fulfilling.
2025 KingLead Nobel Innovation Forum
Dialogue with Nobel Laureates
Open to outstanding students world-wide
The 2025 KingLead Nobel Innovation Forum "Dialogue with Nobel Laureates" is now open to outstanding youth worldwide who have the sense of social responsibility, are willing to devote themselves to innovation, and aspire to become future Nobel scientists for free. Three Nobel Laureates, including Nobel Laureates in Economics, Chemistry, and Physiology or Medicine, will dialogue with outstanding students. Each student will choose a Nobel Laureate based on their future development direction, ask a valuable question on cutting-edge fields such as academics, education, and innovation, and interact with the Nobel Laureate.
Agenda of Dialogue with Nobel Laureates
Date: March 29 morning, 2025
Venue: China National Convention Center
08:40-09:10
Dialogue with Nobel Laureate in Economics
Outstanding students who intend to develop in the fields of economics, finance, mathematics, social sciences, etc.
Number Limit: 10 students
09:20-09:50
Dialogue with Nobel Laureate in Chemistry
Outstanding students who intend to develop in the fields of chemistry, organic chemistry, materials science, etc.
Number Limit: 10 students
10:40-11:10
Dialogue with Nobel Laureate in Physiology or Medicine
For outstanding students who intend to develop in the fields of biology, medicine, health, brain science, neuroscience, etc.
Number Limit: 10 students
Students who have successfully participated in the dialogue will come to the stage of the forum and will be awarded the Honorary Certificate by the Nobel Innovation Platform.
Application Process
Each applicant will need to fill in the registration form truthfully and submit an English resume. The seats are limited and will be filled up on a first-come, first-served basis. Interested students please scan the QR code below or click on the "Read More" button at the bottom left of the article to apply.
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Feb 28, 2025 Application Deadline
Application will be closed. Nobel Innovation Platform Committee will review materials.
2
Mar 5, 2025 Result Notification
Application results will be notified via SMS and email. Admitees need to reply to confirm.
3
Mar 10, 2025 Submit A Question
Each student will submit a question in English for the committee to review.
4
Mar 21, 2025 Pre Departure Matters
The committee will notify students of the order of dialogue, precautions, etc.
5
Mar 29, 2025 Dialogue with Nobel Laureates
Students will need to arrive 15 minutes ahead and talk with Nobel Laureates in order.
Students will come to the stage and will be awarded the Honorary Certificate by Nobel Innovation Platform.
KingLead Nobel Innovation Forum
Dialogue with Nobel Laureates
Students Application Portal
Free to outstanding students worldwide
Application deadline: Feb 28, 2025
来源：京领新国际