摘要：3月25日，爱思唯尔（Elsevier）正式发布2024“中国高被引学者” (Highly Cited Chinese Researchers) 榜单，共计6388人上榜，来自547所高校、企业及科研机构，覆盖了教育部10个学科领域、83个一级学科。其中，化学

3月25日，爱思唯尔（Elsevier）正式发布2024“中国高被引学者” (Highly Cited Chinese Researchers) 榜单，共计6388人上榜，来自547所高校、企业及科研机构，覆盖了教育部10个学科领域、83个一级学科。其中，化学学科高被引学者最多，共501位；生物学、材料科学与工程、临床医学、计算机科学与技术、物理学等学科均超过了200位。此外，科研年限1-10年上榜学者占比2.3%，科研年限11-20年上榜学者占比26.7%。

2024年中国高被引学者所属机构中，中国科学院拥有最多的高被引学者，共533位。高校中，共有10所大学的高被引学者数量超过了100位，分别是清华大学（279位）、浙江大学（256位）、北京大学（219位）、上海交通大学（196位）、复旦大学（159位）、华中科技大学（129位）、中国科学技术大学（120位）、南京大学（117位）、武汉大学（116位）、中山大学（112位）。

小学社整理了临床医学和基础医学领域参与类器官研究的前10位高被引学者，列出了他们各自已发表的类器官相关文章，希望能为广大类器官研究领域的学者们带来研究思路的启发。

临床医学

1. 【滋养层类器官】反复植入失败的女性子宫内膜BMP2缺乏会损害ITGB3介导的滋养层细胞侵袭：Hu C, Deng J, Liu M, et al. Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure. Endocrinology. 2024 Jan 16;165(3):bqae002.

2. 【子宫内膜类器官】骨形态发生蛋白在人类月经周期和妊娠期子宫内膜重塑中的作用：Wei D, Su Y, Leung P, et al. Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy. Hum Reprod Update. 2024 Mar 1;30(2):215-237.

3. 【滋养层类器官】TGF-β超家族蛋白在绒毛外滋养层细胞侵袭中的作用：Li Y, Yan J, Chang H, et al. Roles of TGF-β Superfamily Proteins in Extravillous Trophoblast Invasion. Trends Endocrinol Metab. 2021 Mar;32(3):170-189.

1. 【肝癌类器官】EGR1通过转录下调PFKL抑制HCC生长和有氧糖酵解：Pan M, Luo M, Liu L, et al. EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL. J Exp Clin Cancer Res. 2024 Jan 29;43(1):35.

1. 【胃癌类器官】类器官的构建及其在胃癌中的应用：Huo C, Zhang X, Gu Y, et al. Organoids: Construction and Application in Gastric Cancer. Biomolecules. 2023 May 22;13(5):875.

1. 【心脏类器官】心脏类器官研究进展：对心血管疾病治疗的意义：Huang Z, Jia K, Tan Y, et al. Advances in cardiac organoid research: implications for cardiovascular disease treatment. Cardiovasc Diabetol. 2025 Jan 18;24(1):25.

2. 【心脏类器官】用于心脏病建模和药物评估的人类血管化和腔室化心脏类器官的生成：Yang J, Lei W, Xiao Y, et al. Generation of human vascularized and chambered cardiac organoids for cardiac disease modelling and drug evaluation. Cell Prolif. 2024 Aug;57(8):e13631.

1. 【骨类器官】骨类器官：最新进展和未来挑战：Zhao D, Saiding Q, Li Y, et al. Bone Organoids: Recent Advances and Future Challenges. Adv Healthc Mater. 2024 Feb;13(5):e2302088.

2. 【类器官综述】类器官干细胞：Qian S, Mao J, Liu Z, et al. Stem cells for organoids. Smart Med. 2022 Dec 27;1(1):e20220007.

1. 【肺癌类器官】EGFR突变蛋白在EGFR突变转化小细胞肺癌中的表达及基因组进化：Zhang S, Zhang C, Chen Y, et al. Expression of EGFR-mutant proteins and genomic evolution in EGFR-mutant transformed small cell lung cancer. J Thorac Dis. 2023 Sep 28;15(9):4620-4635.

2. 【肺癌类器官】使用患者来源的类器官预测局部晚期或转移性肺癌肿瘤反应：一项现实世界的研究：Wang H, Zhang C, Peng K, et al. Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study. Cell Rep Med. 2023 Feb 21;4(2):100911.

3. 【肺癌类器官】EGFR+/METamp+与EGFR+/METamp-未治疗的晚期非小细胞肺癌患者的临床结果：Peng K, Su J, Xie Z, et al. Clinical outcomes of EGFR+/METamp+ vs. EGFR+/METamp- untreated patients with advanced non-small cell lung cancer. Thorac Cancer. 2022 Jun;13(11):1619-1630.

4. 【肺癌类器官】肺癌非小细胞类器官的基因组特征及药物筛选：Chen J, Chu X, Zhang J, et al. Genomic characteristics and drug screening among organoids derived from non-small cell lung cancer patients. Thorac Cancer. 2020 Aug;11(8):2279-2290.

1. 【肝类器官】脱细胞肝支架用于构建药物代谢功能性离体人肝模型：Liu J, Hanson A, Yin W, et al. Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models. Bioact Mater. 2024 Sep 23;43:162-180.

2. 【肝癌类器官】靶向肝细胞癌代谢重编程以克服治疗耐药性：综述：Wang Q, Liu J, Chen Z, et al. Targeting metabolic reprogramming in hepatocellular carcinoma to overcome therapeutic resistance: A comprehensive review. Biomed Pharmacother. 2024 Jan;170:116021.

3. 【肝类器官】人肝球体的高含量成像用于研究度洛西汀诱导肝毒性的机制：Liu J, Li R, Zhang T, et al. High-content imaging of human hepatic spheroids for researching the mechanism of duloxetine-induced hepatotoxicity. Cell Death Dis. 2022 Aug 1;13(8):669.

4. 【胆管癌类器官】拉帕替尼抑制HER2过表达胆管癌并克服ABCB1介导的吉西他滨耐药性：Bai Z, Guo Z, Liu J, et al. Lapatinib Suppresses HER2-Overexpressed Cholangiocarcinoma and Overcomes ABCB1- Mediated Gemcitabine Chemoresistance. Front Oncol. 2022 Apr 8;12:860339.

1. 【胆管癌类器官】突变KRAS和CK2协同刺激SLC16A3活性以驱动肝内胆管癌进展：Chen R, Ma C, Qian H, et al. Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression. Cancer Res. 2025 Jan 24.

2. 【脑类器官】MLKL缺陷缓解帕金森病α-突触核蛋白转基因小鼠模型中的神经炎症和运动缺陷：Geng L, Gao W, Saiyin H, et al. MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease. Mol Neurodegener. 2023 Dec 1;18(1):94.

3. 【肝癌类器官】用于精确肿瘤学的肝癌类器官的药物-基因组学特征：Ji S, Feng L, Fu Z, et al. Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology. Sci Transl Med. 2023 Jul 26;15(706):eadg3358.

4. 【肝癌类器官】基因组规模CRISPR筛查确定LAPTM5驱动肝细胞癌对乐伐替尼的耐药性：Pan J, Zhang M, Dong L, et al. Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma. Autophagy. 2023 Apr;19(4):1184-1198.

1. 【脑瘤类器官】CD44/CD133双靶向IL7Rα改造CAR-T细胞抗胶质母细胞瘤的开发及其强效抗肿瘤作用：Zhai Y, Li G, Pan C, et al. The development and potent antitumor efficacy of CD44/CD133 dual-targeting IL7Rα-armored CAR-T cells against glioblastoma. Cancer Lett. 2025 Apr 1;614:217541.

2. 【脑瘤类器官】基于脊髓灰质炎病毒受体的嵌合抗原受体T细胞与NK-92细胞联合对胶质母细胞瘤具有强效活性：Pan C, Zhai Y, Wang C, et al. Poliovirus receptor-based chimeric antigen receptor T cells combined with NK-92 cells exert potent activity against glioblastoma. J Natl Cancer Inst. 2024 Mar 7;116(3):389-400.

1. 【肾类器官】WT1突变的肾脏类器官模型揭示了足细胞发育的关键调控途径：Wang G, Wu H, Zhai X, et al. Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development. Adv Sci (Weinh). 2024 Aug;11(29):e2308556.

2. 【类器官建模】多重散装和单细胞RNA-seq杂交技术能够利用嵌合类器官进行经济高效的疾病建模：Cheng C, Wang G, Zhu Y, et al. Multiplexed bulk and single-cell RNA-seq hybrid enables cost-efficient disease modeling with chimeric organoids. Nat Commun. 2024 May 10;15(1):3946.

3. 【类器官综述】罕见和未确诊疾病：从致病基因鉴定到机制阐明：Wang G, Xu Y, Wang Q, et al. Rare and undiagnosed diseases: From disease-causing gene identification to mechanism elucidation. Fundam Res. 2022 Sep 11;2(6):918-928.

基础医学

1. 【肿瘤类器官】CCT251545通过Rac1介导的大白细胞增多症增强药物递送并增强多药耐药癌症的化疗：Qin S, Zhang Z, Huang Z, et al. CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1-mediated macropinocytosis. Drug Resist Updat. 2023 Jan;66:100906.

2. 【膀胱癌类器官】化疗期间获得性半鳞片化提示为膀胱癌的分化性治疗策略：Wang M, Chen X, Tan P, et al. Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer. Cancer Cell. 2022 Sep 12;40(9):1044-1059.e8.

3. 【胰腺癌类器官】再利用益康唑作为药物自噬抑制剂治疗胰腺导管腺癌：Weng N, Qin S, Liu J, et al. Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma. Acta Pharm Sin B. 2022 Jul;12(7):3085-3102.

1. 【肠道类器官】EFHD2通过阻断肠上皮细胞TNFR1内化和细胞死亡抑制肠道炎症：Wu J, Xu X, Duan J, et al. EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death. Nat Commun. 2024 Feb 12;15(1):1282.

1. 【脑类器官】出生后人类海马神经胶质多样性的单细胞转录组图谱：Su Y, Zhou Y, Bennett ML, et al. A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan. Cell Stem Cell. 2022 Nov 3;29(11):1594-1610.e8.

2. 【脑类器官】用于模拟不同皮质层形成的切片人类皮质类器官：Qian X, Su Y, Adam CD, et al. Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. Cell Stem Cell. 2020 May 7;26(5):766-781.e9.

1. 【肠道类器官】NVP-AUY922通过调节EPHX1缓解放射性肠损伤：Kong W, Ding X, Wang Z, et al. NVP-AUY922 relieves radiation-induced intestinal injury via regulating EPHX1. Life Sci. 2025 Feb 15;363:123382.

2. 【唾液腺类器官】褪黑素改善γ射线照射诱导的小鼠唾液腺损伤：Ren J, Zhu T, Wang Z, et al. Amelioration of gamma irradiation-induced salivary gland damage in mice using melatonin. J Pineal Res. 2023 Sep;75(2):e12897.

1. 【卵巢癌类器官】卵泡液对卵巢癌发病的输卵管上皮细胞生理特性及分化的影响：Zhu M, Wang N, Wang S, et al. Effects of Follicular Fluid on Physiological Characteristics and Differentiation of Fallopian Tube Epithelial Cells Implicating for Ovarian Cancer Pathogenesis. Int J Mol Sci. 2023 Jun 15;24(12):10154.

1. 【肺癌类器官】早期肺腺癌中IL-6和NK细胞减少，表现为磨玻璃样不透明：Zhang P, He B, Cai Q, et al. Decreased IL-6 and NK Cells in Early-Stage Lung Adenocarcinoma Presenting as Ground-Glass Opacity. Front Oncol. 2021 Sep 8;11:705888.

1. 【肿瘤类器官】调节肿瘤SPARC含量以增强癌症治疗中基于白蛋白的药物递送：Zheng B, Chen Y, Niu L, et al. Modulating the tumoral SPARC content to enhance albumin-based drug delivery for cancer therapy. J Control Release. 2024 Feb;366:596-610.

2. 【肾癌类器官】患者来源的肾细胞癌类器官用于个性化癌症治疗：Li Z, Xu H, Yu L, et al. Patient-derived renal cell carcinoma organoids for personalized cancer therapy. Clin Transl Med. 2022 Jul;12(7):e970.

3. 【尿路上皮癌类器官】患者来源的上尿路上皮癌类器官作为药物筛选平台：Li Z, Xu H, Gong Y, et al. Patient-Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening. Adv Sci (Weinh). 2022 Feb;9(4):e2103999.

4. 【肺癌类器官】用于药物筛选的人肺腺癌衍生类器官模型：Li Z, Qian Y, Li W, et al. Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening. iScience. 2020 Aug 21;23(8):101411.

1. 【乳腺癌类器官】PROTAC靶向PRMT5治疗三阴性乳腺癌：Guo Y, Li Y, Zhou Z, et al. Targeting PRMT5 through PROTAC for the treatment of triple-negative breast cancer. J Exp Clin Cancer Res. 2024 Nov 30;43(1):314.

2. 【乳腺癌类器官】PI3K PROTAC克服PIK3CA-突变型HER2阳性乳腺癌对拉帕替尼的耐药性：Zhang H, Zhang L, He Y, et al. PI3K PROTAC overcomes the lapatinib resistance in PIK3CA-mutant HER2 positive breast cancer. Cancer Lett. 2024 Aug 28;598:217112.

3. 【乳腺癌类器官】CDK9靶向PROTAC L055抑制ERα阳性乳腺癌：Chen W, Wu Y, Yang C, et al. CDK9 targeting PROTAC L055 inhibits ERα-positive breast cancer. Biomed Pharmacother. 2024 Aug;177:116972.

4. 【乳腺癌类器官】毒黄素类似物D43通过诱导ROS介导的细胞凋亡和DNA损伤对乳腺癌发挥抗增殖作用：Wu T, Liu W, Chen H, et al. Toxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage. Sci Rep. 2024 Feb 18;14(1):4008.

5. 【乳腺类器官】人成纤维细胞促进iPSC衍生的乳腺样类器官的产生：Dai X, Wang X, Yang C, et al. Human fibroblasts facilitate the generation of iPSCs-derived mammary-like organoids. Stem Cell Res Ther. 2022 Jul 28;13(1):377.

1. 【心脏类器官】C10orf71中的移码变异在人类、小鼠和类器官模型中引起扩张型心肌病：Li Y, Ma K, Dong Z, et al. Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models. J Clin Invest. 2024 Jun 17;134(12):e177172.

1. 【肠癌类器官】IFNγ通过IFNγ/IFNR2/APC/TCF4/GPX4轴与冷大气血浆协同作用触发结直肠癌细胞铁死亡：Lv X, He FL, Dai Y, et al. IFNγ synergieswithcold atmospheric plasmain triggering colorectal cancer cell ferroptosis via the IFNγ/IFNR2/APC/TCF4/GPX4 axis. Aging. 2023 Sep 4;15(17):8692-8711.

来源：培养盒守护者