摘要：Rheumatology & Autoimmunity 2024年第4期，包括10篇风湿病与免疫学领域的论文，欢迎阅读引用。

导 语

Rheumatology & Autoimmunity 2024年第4期，包括10篇风湿病与免疫学领域的论文，欢迎阅读引用。

Review

01 Inflammasomes and their roles in autoimmune diseases

Minghui Pan, Jie Yang, Zhengfan Jiang

本文综述了炎性小体的免疫学功能，并阐明了它们在自身免疫性疾病发病机制中的关键作用，包括类风湿关节炎、系统性红斑狼疮、多发性硬化、炎症性肠病、冷吡啉相关周期性综合征、银屑病、干燥综合征和强直性脊柱炎。

How to cite:Pan M, Yang J, Jiang Z. Inflammasomes and their roles in autoimmune diseases. Rheumatol Autoimmun 2024; 4: 197-217. doi: 10.1002/rai2.12155

02

Expanding the scope of mast cell disease: Does mast cell-derived TNF play a role in immune-mediated chronic illness and autoimmunity?

Rachel da Silveira Gorman, Iffath Unissa Syed

肥大细胞及其衍生的肿瘤坏死因子在慢性炎症性疾病、自身免疫性疾病和病毒后综合征中发挥重要作用，具有重要的作用机制和治疗潜力。大剂量褪黑素和小剂量纳曲酮可调节肥大细胞活化，减少肿瘤坏死因子诱导的炎症，似乎是有前景的治疗方法，可以帮助预防或治疗免疫介导的疾病。

How to cite:da Silveira Gorman R, Syed IU. Expanding the scope of mast cell disease: does mast cell-derived TNF play a role in immune-mediated chronic illness and autoimmunity? Rheumatol Autoimmun 2024; 4: 218-225. doi: 10.1002/rai2.12151

Original Article

03

Impact of coronavirus disease 2019 on psoriatic arthritis: A multiregional observational study

Ranran Yao, Renge Liang, Jing Lu, Hongxia Li, Qiao Zhou, Yuhui Li, Liling Xu, Gong Cheng, Yuan Jia, Yin Su

银屑病关节炎患者感染新型冠状病毒后可能会出现病情加重。此外，活动性银屑病关节炎患者在COVID-19存在时更有可能出现明显的呼吸困难症状。研究表明，接种全剂量（≥2剂次）COVID-19疫苗可有效减轻银屑病关节炎患者的腹泻、疲劳、食欲变化和轴性关节痛等症状。

How to cite: Yao R, Liang R, Lu J, et al. Impact of coronavirus disease 2019 on psoriatic arthritis: A multiregional observational study. Rheumatol Autoimmun 2024; 4: 226-234. doi: 10.1002/rai2.12134

（扫码阅读全文）

04

Sex differences in CXCL4-mediated lung damage in the bleomycin-induced systemic sclerosis mice model

Yi'an Tian, Jingyan Li, Bingrui Yu, Yu Chen, Tianping Bao, Yuhong Li

How to cite: Tian Y, Li J, Yu B, Chen Y, Bao T, Li Y. Sex differences in CXCL4-mediated lung damage in the bleomycin-induced systemic sclerosis mice model. Rheumatol Autoimmun 2024; 4: 235-241. doi: 10.1002/rai2.12136

05

Genetically supported causal genes for rheumatoid arthritis: Mendelian randomization and co-localization analyses

Yuanyuan Niu, Fan Su, Simin Chen, Jingnan Wang, Shuoyang Zhang, Ruiru Li, Yu Kuang, Liuqin Liang, Youjun Xiao, Hanshi Xu

为了探索可能导致类风湿关节炎的潜在基因，本文基于大样本全基因组关联研究的数据进行了全面的孟德尔随机化分析和共定位。共定位分析提示AP4B1、GGA2、KEAP1、PTPN22、REG4、TRAV38-2DV8与类风湿关节炎发病风险存在因果关系。

How to cite: Niu Y, Su F, Chen S, et al. Genetically supported causal genes for rheumatoid arthritis: Mendelian randomization and co-localization analyses. Rheumatol Autoimmun 2024; 4: 242-253. doi: 10.1002/rai2.12145

Case Report

06

Antiphospholipid syndrome followed idiopathic retroperitoneal fibrosis in the same patient: A case report and review of literature

Wanki Ho, Weihao Li, Wenchang Nie, Yunshan Zhou, Chun Li, Yuzhou Gan, Hua Ye

本文报道一例特发性腹膜后纤维化，继发多支静脉难治性血栓形成，随后诊断为抗磷脂抗体综合征。对于继发于特发性腹膜后纤维化的静脉血栓形成病例，重要的是要筛查所有可能的血栓形成倾向的原因。

How to cite: Ho W, Li W, Nie W, et al. Antiphospholipid syndrome followed idiopathic retroperitoneal fibrosis in the same patient: a case report and review of literature. Rheumatol Autoimmun 2024; 4: 254-258. doi: 10.1002/rai2.

12149

Letter to the Editor

07

Matrix calculi in systemic lupus erythematosus complicated by distal renal tubular acidosis in a solitary kidney

Gerry G. Mathew, Varadharajan Jayaprakash

一名系统性红斑狼疮患者在远端肾小管酸中毒和单肾结构异常的情况下发生基质结石，表现为右侧腰痛和血尿。经手术取石、免疫抑制剂及酸碱平衡治疗后，患者病情改善，未见新结石复发。本病例突出了基质结石在系统性红斑狼疮相关疾病中的罕见性和病理机制。

How to cite: Mathew GG, Jayaprakash V. Matrix calculi in systemic lupus erythematosus complicated by distal renal tubular acidosis in a solitary kidney. Rheumatol Autoimmun 2024; 4: 259-261. doi: 10.1002/rai2.12135

08

Submandibular mucosa-associated lymphoid tissue lymphoma in a primary Sjögren's syndrome

Raida Ben Salah, Rim Kallel, Oumaima Chouchene, Tahia Boudawara, Zouhir Bahloul

本案例报道了一名36岁女性患者，因干燥综合征（SS）同时并发黏膜相关淋巴组织（MALT）淋巴瘤而就诊。患者有眼干、口干症状，伴随双侧腮腺肿大及颌下淋巴结肿大。通过抗Ro/SSA抗体阳性和唇腺活检确诊为SS，同时颌下腺组织活检显示MALT型B细胞淋巴瘤。经放射治疗效果良好。SS患者罹患淋巴瘤的风险显著增加，需多学科协作诊治以提高预后。

How to cite: Ben Salah R, Kallel R, Chouchene O, Boudawara T, Bahloul Z. Submandibular mucosa-associated lymphoid tissue lymphoma in a primary Sjögren's syndrome. Rheumatol Autoimmun 2024; 4: 262-264. doi: 10.1002/rai2.12150

09

Low-dose interleukin-2 for the treatment of systemic lupus erythematosus with recurrent rash

Jirong Cheng, Miao He, Di Ma, Xing Li, Yuanhong Peng

本文报告了一名57岁女性系统性红斑狼疮患者，面部蝶形红斑复发，传统治疗效果有限，通过低剂量白细胞介素2疗法显著改善病情，表明其在调节免疫功能和治疗耐药性系统性红斑狼疮中的潜力。

How to cite: Cheng J, He M, Ma D, Li X, Peng Y. Low-dose interleukin-2 for the treatment of systemic lupus erythematosus with recurrent rash. Rheumatol Autoimmun 2024; 4: 265-266. doi: 10.1002/rai2.12148

Clinical Image

10

Rare manifestation of gout: Gouty tophi in unusual locations

Yinzi Chen, Xiangyu Wang, Nan Wang, Guoyun Li, Ruomei Cui, Jian Xu, Yulong Guo, Shuang Liu

本文报道了罕见部位的痛风石。病例一患者胸锁关节、手指关节有痛风石；病例二、三患者眼睑和结膜等部位也出现痛风石。影像学检查确诊痛风性关节炎及骨侵蚀。痛风治疗应以生活方式调整与药物维持低尿酸水平为核心，系统治疗可减少痛风石，严重病例可手术，及时诊断与规范管理对提高患者生活质量至关重要。

How to cite: Chen Y, Wang X, Wang N, et al. Rare manifestation of gout: Gouty tophi in unusual locations. Rheumatol Autoimmun 2024; 4: 267-268. doi: 10.1002/rai2.12143

Rheumatology & Autoimmunity

期刊发表范围

涵盖风湿病学和临床免疫学的各个领域，包括各种风湿病、自身免疫病以及免疫学基础及转化医学研究。

感兴趣的主题

各种风湿病和自身免疫病的基础和临床研究，包括但不限于以下疾病：

• Rheumatoid Arthritis

类风湿关节炎

• Systemic Lupus Erythematosus

系统性红斑狼疮

• Sjogren Syndrome

干燥综合征

• Spondyloarthritis

脊柱关节炎

• Gout

痛风

• Osteoarthritis

骨关节炎

• Psoriatic Arthritis

银屑病关节炎

• Inflammatory Myopathy

炎性肌病

• Systematic Sclerosis

系统性硬化症

• Systemic Vasculitis

系统性血管炎

医脉通是专业的在线医生平台，“感知世界医学脉搏，助力中国临床决策”是平台的使命。医脉通旗下拥有「临床指南」「用药参考」「医学文献王」「医知源」「e研通」「e脉播」等系列产品，全面满足医学工作者临床决策、获取新知及提升科研效率等方面的需求。

来源：医脉通风湿汇一点号