摘要：多发性硬化是一种慢性中枢神经系统疾病，其特征是炎症、脱髓鞘和神经退行性变。了解多发性硬化的早期病变和发展过程有助于早期诊断和干预，从而可能延缓疾病进展近年来多发性硬化机制研究在于深入理解疾病的复杂发病过程，包括菌群、肠-脑轴、非运动症状、运动疗法等方面的探讨，

多发性硬化是一种慢性中枢神经系统疾病，其特征是炎症、脱髓鞘和神经退行性变。了解多发性硬化的早期病变和发展过程有助于早期诊断和干预，从而可能延缓疾病进展近年来多发性硬化机制研究在于深入理解疾病的复杂发病过程，包括菌群、肠-脑轴、非运动症状、运动疗法等方面的探讨，以期为多发性硬化患者提供更有效的治疗手段。

为此，选择本刊学者2023-2024年发表的多发性硬化机制研究的相关综述文章3篇，推荐读者阅读。

(1) Gut flora in multiple sclerosis: implications for pathogenesis and treatment

多发性硬化症中的肠道菌群：对发病机制和治疗的影响

Weiwei Zhang 1, Ying Wang 1, Mingqin Zhu 1, Kangding Liu 1, Hong-Liang Zhang 2

1 Department of Neurology, the First Hospital of Jilin University, Jilin University, Changchun, Jilin Province, China.

2 Department of Life Sciences, National Natural Science Foundation of China, Beijing, China.

引用本文：

Zhang W, Wang Y, Zhu M, Liu K, Zhang HL. Gut flora in multiple sclerosis: implications for pathogenesis and treatment. Neural Regen Res. 2024;19(7):1480-1488.

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(2) Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models

了解多发性硬化症的非运动症状谱：动物模型的启示

Poornima D E Weerasinghe-Mudiyanselage 1, Joong-Sun Kim 1, Taekyun Shin 2, Changjong Moon 1

1 Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, Gwangju, Republic of Korea.

2 Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Republic of Korea.

引用本文：Weerasinghe-Mudiyanselage PDE, Kim JS, Shin T, Moon C. Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models. Neural Regen Res. 2024;19(1):84-91.

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(3) Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis

人类和多发性硬化症临床前模型中的体育锻炼和突触保护

Federica Azzolini 1, Ettore Dolcetti 1, Antonio Bruno 1, Valentina Rovella 2, Diego Centonze 1 3, Fabio Buttari 1 3

1 Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy.

2 Department of System Medicine, University of Tor Vergata, Rome, Italy.

3 Synaptic Immunopathology Lab, Department of Systems Medicine, Tor Vergata University, Rome, Italy.

引用本文：

Azzolini F, Dolcetti E, Bruno A, Rovella V, Centonze D, Buttari F. Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis. Neural Regen Res. 2024;19(8):1768-1771.

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来源：中国神经再生研究杂志